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sofosbuvir

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Origin: China

Cas No: 1190307-88-0

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 1190307-88-0 Formula: C22H29FN3O9P Molecular Weight: 529.45300

    Description

    PSI-7977 is a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.

    Basic Info

    Chemical Name sofosbuvir
    Synonyms

    propan-2-yl (2S)-2-[[[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate;
    GS-7977;
    SOFOSBUVIR;
    (S)-2-{(S)-[(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-ylmethoxy](phenoxy)phosphorylamino}propionic acid isopropyl ester;

    CAS No. 1190307-88-0
    Molecular Formula C22H29FN3O9P
    Molecular Weight 529.45300
    PSA 167.99000
    LogP 2.04740

    Synthesis Route

    (2'R)-2'-Deoxy-2'-fluoro-2'-methyl-uridine+(S)-2-[(S)-(4-nitro-phenoxy)-phenoxy-phosphorylamino]propionic acid isopropyl ester→sofosbuvir
    5'-O-(isopropyl-L-alanate,phenyl-phosphoramidyl)-2'-deoxy-2'-fluoro-2'-C-methyl-uridine→sofosbuvir
    (2'R)-2'-Deoxy-2'-fluoro-2'-methyl-uridine+(S)-2-[(R)-(4-nitro-phenoxy)-phenoxy-phosphorylamino]propionic acid isopropyl ester→sofosbuvir+sofosbuvir

    Precursor

    (S)-2-[(S)-(4-nitro-phenoxy)-phenoxy-phosphorylamino]propionic acid isopropyl ester
    propan-2-yl (2S)-2-[[(2,3,4,5,6-pentafluorophenoxy)-phenoxyphosphoryl]amino]propanoate
    5'-O-(isopropyl-L-alanate,phenyl-phosphoramidyl)-2'-deoxy-2'-fluoro-2'-C-methyl-uridine
    (2'R)-2'-Deoxy-2'-fluoro-2'-methyl-uridine

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