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(R)-Boc-Nipecotic Acid

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Origin: China

Cas No: 163438-09-3

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description

  • Quick Details

    CAS No.:
    163438-09-3
    Other Names:
    (R)-1-Boc-piperidine-3-carboxylic acid
    MF:
    C11H19NO4
    EINECS No.:
    163438-09-3
    Place of Origin:
    Shaanxi, China
    Type:
    Agrochemical Intermediates, Dyestuff Intermediates, Flavor & Fragrance Intermediates, Pharmaceutical Intermediates, Syntheses Material Intermediates
    Purity:
    99%min
    Brand Name:
    DIDAC
    Model Number:
    DAC170112
    Application:
    Pharm/Chem Industries
    Appearance:
    Liquid Form
    Structure Identification:
    H-NMR&LC-MS
    Identification:
    Infrared Absorption
    Test method:
    HPLC-ESI-MS
    Content:
    99.0% to 101.0%
    Water:
    0.5% Max.
    Sulfated ash:
    0.1% Max.
    Heavy metals:
    10ppm Max
    Total Impurity:
    0.2% Max.
    Assay:
    HPLC
    Disregard limit:
    0.0005%

    Packaging&Delivery

    Packaging Details
    25kgs/Drum; 200kgs/Drum
    Port
    Any main port of China

    Products Description

    Item
    Standard
    Test Results





    Identification
    A.H-NMR:Comply with the structure
    Complies
    B.LC-MS:Comply with the structure
    Complies
    C.The IR spectrum of sample should be identical with that of reference standard;
    Complies
    D.HPLC-ESI-MS
    The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the
    Standard preparation, as obtained in the Assay.
    Complies
    Crystallinity
    meets the requirements.
    Complies
    Loss on drying
    ≤2.0%
    0.19%
    Heavy metals
    ≤10 ppm
    <10ppm
    Water
    ≤1.0%
    0.1%
    Sulphated ash
    ≤0.5%, determined on 1.0 g.
    0.009%

    Related substances
    Unspecified impurities: for each impurity ≤0.10%
    <0.10%
    Total Impurity ≤0.5%
    0.18%
    Purity
    ≥99.0%
    99.7%
    Assay
    99.0%~101.0% (anhydrous substance).
    99.8%
    Storage
    Preserve in well-closed, light-resistant and airtight containers.
    Complies

  • Property

    CAS No.: 163438-09-3 Formula: C11H19NO4 Molecular Weight: 229.27300

    Basic Info

    Chemical Name (R)-Boc-Nipecotic Acid
    Synonyms

    (R)-N-BOC-piperidine-3-carboxylic acid;
    1-Boc-D-nipecotic acid;
    (R)-Boc-Nip-OH;
    (3R)-1-[(2-methylpropan-2-yl)oxycarbonyl]piperidine-3-carboxylic acid;
    (R)-1-(tert-Butoxycarbonyl)piperidine-3-carboxylic acid;
    N-Boc-R-3-carboxylic acid piperidine;
    (R)-1-Boc-nipecotic Acid;

    CAS No. 163438-09-3
    Molecular Formula C11H19NO4
    Molecular Weight 229.27300
    PSA 66.84000
    LogP 1.65600

    Properties

    Appearance & Physical State White solid
    Density 1.164 g/cm3
    Boiling Point 353.2ºC at 760 mmHg
    Flash Point 167.4ºC
    Vapor Pressure 6.15E-06mmHg at 25°C

    Safety Info

    Safety Statements S26-S36
    HS Code 2933399090
    WGK Germany 3
    Risk Statements R36/37/38
    Hazard Codes Xi
    Caution Statement P261; P305 + P351 + P338
    Hazard Declaration H315; H319; H335
    Signal Word Warning
    Symbol GHS07

    Synthesis Route

    tert-butoxycarbonyl anhydride+nipecotic acid→(R)-Boc-Nipecotic Acid
    tert-butoxycarbonyl anhydride→(R)-Boc-Nipecotic Acid
    1-[(2-methylpropan-2-yl)oxycarbonyl]-3,6-dihydro-2H-pyridine-5-carboxylic acid→(R)-Boc-Nipecotic Acid

    Precursor

    tert-butoxycarbonyl anhydride
    1-[(2-methylpropan-2-yl)oxycarbonyl]-3,6-dihydro-2H-pyridine-5-carboxylic acid
    1-O-tert-butyl 3-O-ethyl (3R)-piperidine-1,3-dicarboxylate
    nipecotic acid

    Downstream Product

    2-Methyl-2-propanyl (3R)-3-[methoxy(methyl)carbamoyl]-1-piperidin ecarboxylate
    methyl N-[2-[(3-chlorophenyl)-[(3R)-1-[[(2S)-2-(methylamino)-3-[(3R)-oxan-3-yl]propyl]carbamoyl]piperidin-3-yl]methoxy]ethyl]carbamate,2,2,2-trifluoroacetic acid
    1-O-tert-butyl 3-O-methyl (3R)-piperidine-1,3-dicarboxylate
    tert-butyl (3S)-3-(1H-benzimidazol-2-yl)piperidine-1-carboxylate

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