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Montelukast EP Impurity F

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Origin: China

Cas No: 937275-23-5

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 937275-23-5 Formula: C34H32ClNO3S Molecular Weight: 570.14100

    Description

    Montelukast impurity. A leukotriene antagonist useful as anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agent.

    Basic Info

    Chemical Name Montelukast EP Impurity F
    Synonyms

    2-[1-[[(1R)-3-(2-acetylphenyl)-1-[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid;
    (R)-2-(1-(((3-(2-acetylphenyl)-1-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)propyl)thio)methyl)cyclopropyl)acetic acid;

    CAS No. 937275-23-5
    Molecular Formula C34H32ClNO3S
    Molecular Weight 570.14100
    PSA 92.56000
    LogP 8.92320

    Synthesis Route

    (1-bromomethyl-cyclopropyl)-acetic acid methyl ester+(R,E)-2-(2-(3-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-mercaptopropyl)phenyl)propan-2-ol 4-methylbenzenesulfonate→Montelukast EP Impurity F+montelukast
    cyclohexanamine (R,E)-2-(1-(((3-(2-acetylphenyl)-1-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)propyl)thio)methyl)cyclopropyl)acetate→Montelukast EP Impurity F
    Methyl [S-(E)]-2-[3-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-methanesulfonyloxy-propyl] benzoate→Montelukast EP Impurity F

    Precursor

    (R,E)-2-(2-(3-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-mercaptopropyl)phenyl)propan-2-ol 4-methylbenzenesulfonate
    Methyl 2-(3-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-oxopropyl)benzoate
    Methyl [S-(E)]-2-[3-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-methanesulfonyloxy-propyl] benzoate
    cyclohexanamine (R,E)-2-(1-(((3-(2-acetylphenyl)-1-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)propyl)thio)methyl)cyclopropyl)acetate

    Downstream Product

    montelukast

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