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metolazone

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Origin: China

Cas No: 17560-51-9

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
CAS No.:
17560-51-9
MF:
C16H16ClN3O4S
EINECS No.:
241-539-3
Purity:
98%
Appearance:
white powder
Color:
White Power
Shelf life:
2 Years
purity:
98%
Packaging&Delivery
Selling Units:
Single item
Single package size:
20X20X30 cm
Single gross weight:
1.100 kg
Lead Time:
Quantity(Kilograms) 1 - 1000 >1000
Est. Time(days) 5 To be negotiated

Property

CAS No.: 17560-51-9 Formula: C16H16ClN3O3S Molecular Weight: 365.83500

Description

Metolazone is a thiazide-like diuretic marketed under the brand names Zytanix from Zydus Cadila, Zaroxolyn, and Mykrox. It is primarily used to treat congestive heart failure and high blood pressure. Metolazone indirectly decreases the amount of water reabsorbed into the bloodstream by the kidney, so that blood volume decreases and urine volume increases. This lowers blood pressure and prevents excess fluid accumulation in heart failure. Metolazone is sometimes used together with loop diuretics such as furosemide or bumetanide, but these highly effective combinations can lead to dehydration and electrolyte abnormalities.

Basic Info

Chemical Name	metolazone
Synonyms	Metolazone; 7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2-dihydroquinazoline-6-sulfonamide; 7-Chloro-2-methyl-4-oxo-3-(o-tolyl)-1,2,3,4-tetrahydroquinazoline-6-sulfonamide; 7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide;
CAS No.	17560-51-9
Molecular Formula	C16H16ClN3O3S
Molecular Weight	365.83500
PSA	100.88000
LogP	4.69820

Properties

Appearance & Physical State	White to off-white crystalline powder
Density	1.4 g/cm3
Melting Point	255 - 257ºC
Flash Point	324.9ºC
Refractive Index	1.624
Stability	Stable at room temperature in closed containers under normal storage and handling conditions.
Storage Condition	Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from light.
Vapor Pressure	7.82E-15mmHg at 25°C

Safety Info

RTECS	VA1700000
HS Code	2935009090

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Oral	TDLo - Lowest published toxic dose	Human - man	2 mg/kg/2W-I	1.Vascular-structural changes in vessels
Oral	TDLo - Lowest published toxic dose	Human - woman	150 ug/kg	1.Behavioral-general anesthetic 2.Behavioral-convulsions or effect on seizure threshold 3.Behavioral-muscle contraction or spasticity
Oral	LD50 - Lethal dose, 50 percent kill	Rodent - rat	>5 gm/kg	1.Details of toxic effects not reported other than lethal dose value