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metoclopramide

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Origin: China

Cas No: 364-62-5

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description
  • Property

    CAS No.: 364-62-5 Formula: C14H19ClD3N3O2 Molecular Weight: 302.81500

    Description

    Metoclopramide is a medication used mostly for stomach and esophageal problems. It is commonly used to treat nausea and vomiting, to help with emptying of the stomach in people with delayed stomach emptying due to either diabetes or following surgery, and to help with gastroesophageal reflux disease. It is also used to treat migraine headaches.
    Common side effects include: feeling tired, diarrhea, and feeling restless. More serious side effects include: movement disorder like tardive dyskinesia, a condition called neuroleptic malignant syndrome, and depression. It is thus rarely recommended that people take the medication for longer than twelve weeks. It is pregnancy category B in the United States and category A in Australia, meaning no evidence of harm has been found after being taken by many pregnant women. It belongs to the group of medications known as dopamine-receptor antagonists.
    In 2012, metoclopramide was one of the top 100 most prescribed medications in the United States. It is on the World Health Organization's List of Essential Medicines, the most important medication needed in a basic health system. It is avaliable as a generic medication. The wholesale cost in the developing world as of 2014 is 0.003 to 0.08 USD per pill. In the United States a month worth of medication is generally less than 25 USD.

    Basic Info

    Chemical Name metoclopramide
    Synonyms

    4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide;
    4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide,Methoxychloroprocainamide;
    MetoclopraMide;

    CAS No. 364-62-5
    Molecular Formula C14H19ClD3N3O2
    Molecular Weight 302.81500
    PSA 67.59000
    LogP 2.97450

    Properties

    Density 1.162 g/cm3
    Boiling Point 418.7ºC at 760 mmHg
    Melting Point 146-148ºC
    Flash Point 207ºC
    Refractive Index 1.553

    Safety Info

    HS Code 2924299090
    WGK Germany 3

    Synthesis Route

    4-Amino-5-chloro-2-methoxybenzoic acid+N,N-Diethylethylenediaminemetoclopramide
    4-Amino-5-chloro-2-methoxybenzoic acidmetoclopramide
    5-chloro-N-(2-(diethylamino)ethyl)-4-(((dimethylamino)methylene)amino)-2-methoxybenzamidemetoclopramide

    Precursor

    N,N-Diethylethylenediamine
    5-chloro-N-(2-(diethylamino)ethyl)-4-(((dimethylamino)methylene)amino)-2-methoxybenzamide
    1-methanesulfonyloxy-1,2,3-benzotriazole
    carbon monoxide

    Downstream Product

    Cloxacepride
    4-Amino-5-chloro-N-[2-(ethylamino)ethyl]-2-methoxybenzamide
    4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-(3-oxobutan-2-yloxy)benzamide,hydrochloride
    4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-hydroxybenzamide,hydrochloride

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