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Methyl 2-(4-(4-((4-((4-hydroxyphenyl)(phenyl)methyl)piperidin-1-yl)oxy)butyl)phenyl)-2-methylpropanoate

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Origin: China

Cas No: 154477-55-1

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
CAS No.:
154477-55-1
MF:
C33H39NO4
Purity:
98%
Appearance:
N/A
CAS:
154477-55-1
Molecular Formula:
C33H39NO4
Assay:
98%
Packaging&Delivery
Selling Units:
Single item
Single package size:
20X20X30 cm
Single gross weight:
1.100 kg
Lead Time:
Quantity(Kilograms) 1 - 1000 >1000
Est. Time(days) 10 To be negotiated

Property

CAS No.: 154477-55-1 Formula: C33H39NO4 Molecular Weight: 513.66700

Description

1-Oxo Fexofenadine Methyl Ester, is an intermediate in the preparation of Fexofenadine. It can also be used for the synthesis of an oxidation metabolite of Terfenadine,a H1-receptor antagonist.

Basic Info

Chemical Name	Methyl 2-(4-(4-((4-((4-hydroxyphenyl)(phenyl)methyl)piperidin-1-yl)oxy)butyl)phenyl)-2-methylpropanoate
Synonyms	methyl 2-[4-[4-[4-[(4-hydroxyphenyl)-phenylmethyl]piperidin-1-yl]oxybutyl]phenyl]-2-methylpropanoate;
CAS No.	154477-55-1
Molecular Formula	C33H39NO4
Molecular Weight	513.66700
PSA	66.84000
LogP	5.68610

Properties

Density	1.131
Boiling Point	657.185ºC at 760 mmHg
Refractive Index	1.573
Vapor Pressure	0mmHg at 25°C

Synthesis Route

methyl 3,3,3-trideuterio-2-[4-[4-[4-[hydroxy(diphenyl)methyl]piperidin-1-yl]but-1-ynyl]phenyl]-2-(trideuteriomethyl)propanoate→Methyl 2-(4-(4-((4-((4-hydroxyphenyl)(phenyl)methyl)piperidin-1-yl)oxy)butyl)phenyl)-2-methylpropanoate
1-(4-bromophenyl)-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butan-1-one+(1-methoxy-2-methylprop-1-enoxy)-trimethylsilane→Methyl 2-(4-(4-((4-((4-hydroxyphenyl)(phenyl)methyl)piperidin-1-yl)oxy)butyl)phenyl)-2-methylpropanoate
Diphenyl(piperidin-4-yl)methanol+4-(4-Chloro-1-oxobutyl)-α,α-dimethylbenzeneacetic Acid Methyl Ester→Methyl 2-(4-(4-((4-((4-hydroxyphenyl)(phenyl)methyl)piperidin-1-yl)oxy)butyl)phenyl)-2-methylpropanoate

Precursor

methyl 3,3,3-trideuterio-2-[4-[4-[4-[hydroxy(diphenyl)methyl]piperidin-1-yl]but-1-ynyl]phenyl]-2-(trideuteriomethyl)propanoate
1-(4-bromophenyl)-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butan-1-one
4-(4-Chloro-1-oxobutyl)-α,α-dimethylbenzeneacetic Acid Methyl Ester
Diphenyl(piperidin-4-yl)methanol

Downstream Product

Fexofenadinone
methyl 2-[4-[1-hydroxy-4-[4-[hydroxy(diphenyl)methyl]piperidin-1-yl]butyl]phenyl]-2-methylpropanoate
fexofenadine

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