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Home > All categories> Biochemicals and Pharmaceutical Chemicals> Active Pharmaceutical Ingredients (APIs)> Respiratory system> methapyrilene
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methapyrilene

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Origin: China

Cas No: 91-80-5

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 91-80-5 Formula: C14H19N3S Molecular Weight: 261.38600

    Description

    Methapyrilene is an antihistamine and anticholinergic of the pyridine chemical class which was developed in the early 1950s. It was sold under the trade names Co-Pyronil and Histadyl EC. It has relatively strong sedative effects, to the extent that its primary use was as a medication for insomnia rather than for its antihistamine action. Together with scopolamine, it was the main ingredient in Sominex, Nytol, and Sleep-Eze. It also provided the sedative component of Excedrin PM. All of these products were reformulated in the late 1970s when methapyrilene was demonstrated to cause liver cancer in rats when given chronically.

    Basic Info

    Chemical Name methapyrilene
    Synonyms

    1,2-Ethanediamine, N,N-dimethyl-N‘-2-pyridinyl-N‘-(2-thienylmethyl)-;
    Semikon;
    Tenalin;
    Thenylene;
    Thionylan;
    Pyrinistol;
    Pyrinistab;
    Restryl;
    metapyrilene;
    N,N-dimethyl-N'-pyridin-2-yl-N'-(thiophen-2-ylmethyl)ethane-1,2-diamine;
    Methapyrilen;
    Thenylpyramine;
    Paradormalene;

    CAS No. 91-80-5
    Molecular Formula C14H19N3S
    Molecular Weight 261.38600
    PSA 47.61000
    LogP 2.71130

    Properties

    Appearance & Physical State colourless liquid
    Boiling Point 173 - 175ºC at 3 mm Hg
    Stability Stable. Incompatible with strong oxidizing agents.

    Safety Info

    Hazard Class 6.1(b)
    Packing Group III
    RIDADR UN 1851

    GC Analysis

    Column type Active phase Temperature (°C) Retention Index (I) Temperature Control Method
    Capillary BP-1 200. 1981. isothermal
    Capillary BP-1 200. 1993. isothermal
    Packed OV-1 200. 1985. isothermal
    Capillary SE-30 - 1974. temperature ramp
    Packed OV-101 - 1980. custom temperature program

    Toxicity

    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    Subcutaneous LD50 - Lethal dose, 50 percent kill Rodent - rat 150 mg/kg 1.Behavioral-convulsions or effect on seizure threshold
    2.Behavioral-excitement
    3.Behavioral-aggression
    Oral LD50 - Lethal dose, 50 percent kill Rodent - mouse 182 mg/kg 1.Behavioral-somnolence (general depressed activity)
    2.Behavioral-convulsions or effect on seizure threshold
    Intraperitoneal LD50 - Lethal dose, 50 percent kill Rodent - mouse 77 mg/kg 1.Details of toxic effects not reported other than lethal dose value

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