Home > All categories> Biochemicals and Pharmaceutical Chemicals> Active Pharmaceutical Ingredients (APIs)> Respiratory system> mepyramine

mepyramine

Get Latest Price >

FOB Price contact us for price

Origin: China

Cas No: 91-84-9

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

Vendor:

Payment Terms:

Inquiry now

* Send an Inquiry to us

Add to wishlist

* Name your price
* Start order doesn't mean buying now

Products Specification
Product Description

Property

CAS No.: 91-84-9 Formula: C17H23N3O Molecular Weight: 285.38400

Description

Mepyramine, also known as pyrilamine, is a first generation antihistamine, targeting the H1 receptor. However, it rapidly permeates the brain often causing drowsiness. It also has anticholinergic properties. It is used in over-the-counter combination products to treat the common cold and menstrual symptoms. It is also the active ingredient of the topical antihistamine creams Anthisan and Neoantergan, sold for the treatment of insect bites, stings, and nettle rash.

Basic Info

Chemical Name	mepyramine
Synonyms	Pyranisamine; N-[(4-methoxyphenyl)methyl]-N',N'-dimethyl-N-2-pyridinyl-1,2-ethanediamine; Mepiramine; Histapyran; Mepyramine(R); Neoantergan; N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-pyridin-2-ylethane-1,2-diamine; Anhistabs; Antalergan; 1,2-Ethanediamine, N-[(4-methoxyphenyl)methyl]-N‘,N‘-dimethyl-N-2-pyridinyl-; pyrilamine; Mepyramine; Antallergan; Dorantamin; [13C]-Pyrilamine;
CAS No.	91-84-9
Molecular Formula	C17H23N3O
Molecular Weight	285.38400
PSA	28.60000
LogP	2.65840

Properties

Boiling Point	201ºC at 5 MM HG

Synthesis Route

1-(bromomethyl)-4-methoxybenzene→mepyramine
4-Methoxybenzylchloride→mepyramine
2-dimethylaminoethyl chloride→mepyramine

GC Analysis

Column type	Active phase	Temperature (°C)	Retention Index (I)	Temperature Control Method
Capillary	SE-30	-	2225.	temperature ramp
Packed	OV-101	-	2250.	custom temperature program
Packed	SE-30	-	2204.	custom temperature program
Packed	Carbowax 20M	-	3134.	custom temperature program
Capillary	OV-1	-	2228.9	temperature ramp

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Administration into the eye	Standard Draize test	Rodent - rabbit	1%	-
Administration into the eye	Standard Draize test	Rodent - rabbit	100 mg	-
Unreported	TDLo - Lowest published toxic dose	Human	714 ug/kg	1.Behavioral-sleep 2.Behavioral-somnolence (general depressed activity) 3.Behavioral-muscle contraction or spasticity