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mefenamic acid

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Origin: China

Cas No: 61-68-7

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 61-68-7 Formula: C15H15NO2 Molecular Weight: 241.28500

    Description

    Mefenamic acid is a member of the anthranilic acid derivatives (or fenamate) class of NSAID drugs, and is used to treat mild to moderate pain, including menstrual pain, and is sometimes used to prevent migraines associated with menstruation. It is not widely used due to its side effects.:334; Its name derives from its systematic name, dimethylphenylaminobenzoic acid. It was discovered and brought to market by Parke-Davis in the 1960s under brandnames Ponstan, Ponstan Forte, Ponalar, Ponstyl, and Ponstel. It became generic in the 1980s and is available worldwide under many brand names. As of 2015 the cost for a typical course of medication in the United States is more than 200 USD.

    Basic Info

    Chemical Name mefenamic acid
    Synonyms

    Mefenamic Acid;

    CAS No. 61-68-7
    Molecular Formula C15H15NO2
    Molecular Weight 241.28500
    PSA 49.33000
    LogP 3.81820

    Properties

    Appearance & Physical State light yellow solid
    Density 1.203 g/cm3
    Boiling Point 398.8ºC at 760 mmHg
    Melting Point 230ºC
    Flash Point 195ºC
    Refractive Index 1.639
    Storage Condition Refrigerator

    Safety Info

    RTECS CB4550000
    Safety Statements S22-S36/37
    HS Code 2922499990
    WGK Germany 3
    Risk Statements R22
    Hazard Codes Xn

    Synthesis Route

    2-[(2,3-dimethylphenyl)amino]benzonitrile→mefenamic acid
    2,3-Dimethylaniline+2-chlorobenzoic acid→mefenamic acid
    Diphenyliodonium-2-carboxylate+2,3-Dimethylaniline→mefenamic acid

    Toxicity

    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    Oral TDLo - Lowest published toxic dose Human - man 14285 ug/kg/3D-I 1.Nutritional and Gross Metabolic-changes in potassium
    2.Nutritional and Gross Metabolic-other changes
    Oral LDLo - Lowest published lethal dose Human - woman 280 mg/kg/2W-I 1.Liver-liver function tests impaired
    2.Kidney, Ureter, Bladder-changes in tubules (including acute renal failure, acute tubular necrosis)
    3.Blood-other hemolysis with or without anemia
    Oral TDLo - Lowest published toxic dose Human - man 840 mg/kg/6W-I 1.Gastrointestinal-ulceration or bleeding from large intestine
    2.Gastrointestinal-hypermotility, diarrhea

    Precursor

    2-[(2,3-dimethylphenyl)amino]benzonitrile
    Diphenyliodonium-2-carboxylate
    2-iodobenzoic acid
    2,3-Dimethylaniline

    Downstream Product

    2,3-dihydroxypropyl 2-(2,3-dimethylanilino)benzoate
    ethoxymethyl 2-(2,3-dimethylanilino)benzoate
    3-pyridin-4-ylpropyl 2-(2,3-dimethylanilino)benzoate
    (2-methoxyphenyl) 2-(2,3-dimethylanilino)benzoate

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