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medroxyprogesterone

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Origin: China

Cas No: 520-85-4

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

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Product Description

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CAS No.: 520-85-4 Formula: C22H32O3 Molecular Weight: 344.48800

Description

Medroxyprogesterone (INN, BAN), also known as 17α-hydroxy-6α-methylprogesterone, and abbreviated as MP, is a steroidal progestin drug which was never marketed for use in humans. An acylated derivative, medroxyprogesterone acetate (MPA), is clinically used as a pharmaceutical medicine. Compared to MPA, MP is over two orders of magnitude less potent as a progestogen. As such, MP itself is not used clinically, though it has seen limited use in veterinary medicine under the trade name Controlestril in France. In addition, it is a metabolite of MPA.
While medroxyprogesterone is sometimes used as a synonym for medroxyprogesterone acetate, what is normally being administered is MPA and not MP.

Basic Info

Chemical Name	medroxyprogesterone
Synonyms	Medroxyprogesteron; 17-Hydroxy-6alpha-methylprogesterone; Medroxyprogesteronum; Medroxy Progesterone; Medrossiprogesterone; Pregn-4-ene-3,20-dione, 17-hydroxy-6-methyl-, (6α)-; Farlutal; Hydroxymethylprogesterone; 17alpha-Hydroxy-6alpha-methylprogesterone; (6S,8R,9S,10R,13S,14S,17R)-17-acetyl-17-hydroxy-6,10,13-trimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one; Medroxyprogesterone; Medroxiprogesteronum;
CAS No.	520-85-4
Molecular Formula	C22H32O3
Molecular Weight	344.48800
PSA	54.37000
LogP	4.08440

Properties

Density	1.13g/cm3
Boiling Point	488ºC at 760mmHg
Melting Point	220-223.5ºC
Flash Point	263ºC
Refractive Index	1.538
Storage Condition	Refrigerator

Safety Info

Risk Statements	R48; R63; R68
Hazard Codes	Xn
Hazard Declaration	H361
Caution Statement	P281
Symbol	GHS08
Signal Word	Warning

Synthesis Route

5,17-dihydroxy-6β-methyl-5α-pregnane-3,20-dione→medroxyprogesterone
3β,5,17-trihydroxy-6β-methyl-5α-pregnan-20-one→medroxyprogesterone
6β-Methyl-3,20-bis-ethylendioxy-pregnandiol-(5α,17α)-11-on→medroxyprogesterone

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Parenteral	TDLo - Lowest published toxic dose	Human - woman	6 mg/kg/13W-I	1.Peripheral Nerve and Sensation-sensory change involving peripheral nerve 2.Behavioral-hallucinations, distorted perceptions 3.Lungs, Thorax, or Respiration-other changes
Oral	TDLo - Lowest published toxic dose	Rodent - rat	20 mg/kg,female 17-20 day(s) after conception	1.Reproductive-Specific Developmental Abnormalities-urogenital system
Subcutaneous	TDLo - Lowest published toxic dose	Rodent - rat	625 mg/kg,female 10 day(s) pre-mating	1.Reproductive-Maternal Effects-ovaries, fallopian tubes 2.Reproductive-Maternal Effects-uterus, cervix, vagina

Precursor

17α-Hydroxypregn-5-ene-3,20-dione-3,20-bis(ethyleneketal)
3β,5,17-trihydroxy-6β-methyl-5α-pregnan-20-one
6β-Methyl-3,20-bis-ethylendioxy-pregnandiol-(5α,17α)-11-on
5,17-dihydroxy-6β-methyl-5α-pregnane-3,20-dione

Downstream Product

megestrol acetate
megestrol
medroxyprogesterone acetate

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