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matrine

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Origin: China

Cas No: 519-02-8

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

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CAS No.: 519-02-8 Formula: C15H24N2O Molecular Weight: 248.36400

Description

(+)-Matrine is an alkaloid compound extracted from the roots of Sophora species which maintain anti-inflammatory, anti-cancer and a host of other positive pharmacological effects. Apoptotic agent.

Basic Info

Chemical Name	matrine
Synonyms	MATRINIUM; Matridin-15-on; MATRENE; MASSMARK 1621; (7aS,13aR,13bR,13cS)-dodecahydro-1H,5H,10H-dipyrido[2,1-f:3’,2’,1’-ij][1,6]naphthyridin-10-one; Matrines; matridin-15-one; Matrine; Sophocarpidine; Maca extract;
CAS No.	519-02-8
Molecular Formula	C15H24N2O
Molecular Weight	248.36400
PSA	23.55000
LogP	1.74750

Properties

Density	1.16 g/cm3
Boiling Point	396.7ºC at 760 mmHg
Melting Point	77ºC
Flash Point	172.7ºC
Refractive Index	1.536

Safety Info

Safety Statements	S22; S26; S36/37/39; S45
HS Code	1302199001
Risk Statements	R20/21/22
Hazard Codes	Xn

Synthesis Route

OXYSOPHOCARPINE+oxymatrine→matrine
tert-butyl pyridine-3-carboxylate→matrine
1-Allyl-2-oxo-1,4-dihydro-2H-pyridine-3,3-dicarboxylic acid dimethyl ester→matrine

GC Analysis

Column type	Active phase	Temperature (°C)	Retention Index (I)	Temperature Control Method
Capillary	DB-1	-	2286.	temperature ramp
Capillary	DB-1	-	2265.	temperature ramp

Precursor

1-Allyl-2-oxo-1,4-dihydro-2H-pyridine-3,3-dicarboxylic acid dimethyl ester
oxymatrine
1-[5-(5-tert-Butoxycarbonyl-3,4-dihydro-2H-pyridin-1-yl)-2-ethoxythiocarbonylsulfanyl-5-oxo-pentyl]-2-oxo-1,4-dihydro-2H-pyridine-3,3-dicarboxylic acid dimethyl ester
tert-butyl pyridine-3-carboxylate

Downstream Product

4-(2-Biphenylyl)-1-(hydroxymethyl)-10-oxa-4-azatricyclo[5.2.1.0<sup>2,6</sup>]dec-8-ene-3,5-dione
oxymatrine

Sophocarpine

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