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L-Homocysteine

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Origin: China

Cas No: 6027-13-0

Specification: 99%min

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Supply Ability: 50 mt/month

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CAS No.: 6027-13-0 Formula: C4H9NO2S Molecular Weight: 135.18500

Description

Homocysteine is a non-protein α-amino acid. It is a homologue of the amino acid cysteine, differing by an additional methylene bridge (-CH2-). It is biosynthesized from methionine by the removal of its terminal Cε methyl group. Homocysteine can be recycled into methionine or converted into cysteine with the aid of certain B-vitamins.
A high level of homocysteine in the blood (hyperhomocysteinemia) makes a person more prone to endothelial cell injury, which leads to inflammation in the blood vessels, which in turn may lead to atherogenesis, which can result in ischemic injury. Hyperhomocysteinemia is therefore a possible risk factor for coronary artery disease. Coronary artery disease occurs when an atherosclerotic plaque blocks blood flow to the coronary arteries, which supply the heart with oxygenated blood.
Hyperhomocysteinemia has been correlated with the occurrence of blood clots, heart attacks and strokes, though it is unclear whether hyperhomocysteinemia is an independent risk factor for these conditions. Hyperhomoscyteinemia has also been associated with early pregnancy loss and with neural tube defects.

Basic Info

Chemical Name	L-Homocysteine
Synonyms	(S)-2-Amino-4-mercaptobutyric acid; L-2-Amino-4-Mercapto-butyric acid; (S)-2-AMINO-4-MERCAPTOBUTANOIC ACID; Butanoic acid, 2-amino-4-mercapto-, (S)-; L-Homocysteine; (S)-HOMOCYSTEINE; (2S)-2-aMino-4-sulfanylbutanoic acid; HOMO-CYS; H-Hcys-OH;
CAS No.	6027-13-0
Molecular Formula	C4H9NO2S
Molecular Weight	135.18500
PSA	102.12000
LogP	0.41850

Properties

Appearance & Physical State	Colourless or nearly colourless solid
Density	1.259 g/cm3
Boiling Point	299.7ºC at 760 mmHg
Flash Point	135ºC

Synthesis Route

L-cystathionine→L-Homocysteine+Pyruvic acid
Glutathione+N<sup>5</sup>-((R)-3-(((S)-3-amino-3-carboxypropyl)disulfanyl)-1-((carboxymethyl)amino)-1-oxopropan-2-yl)-L-glutamine→glutathione disulfide+L-Homocysteine
L-cystathionine→L-Cysteine+L-Homocysteine

Precursor

L-homocysteine thiolactone
L-methionine
L-Homocystine
2H-1,3-Thiazine-4-carboxylicacid,tetrahydro-,(4S)-(9CI)

Downstream Product

L-cystathionine
hydrogen sulfide
Glutathione
Water

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