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histamine

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Origin: China

Cas No: 51-45-6

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
CAS No.:
51-45-6
Other Names:
Histamine
MF:
C5H9N3
EINECS No.:
200-100-6
Place of Origin:
Hubei, China
Purity:
98%min
Classification:
General Reagents
Brand Name:
WS BIO
Model Number:
Watson
Appearance:
White crystal or crystalline powder
Storage:
Cool Dry Place
Packaging&Delivery
Packaging Details
1g,5g/foil bag or bottle
Port
Any port of China

Property

CAS No.: 51-45-6 Formula: C5H9N3 Molecular Weight: 111.14500

Description

Histamine is an organic nitrogenous compound involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter. Histamine is involved in the inflammatory response and has a central role as a mediator of pruritus. As part of an immune response to foreign pathogens, histamine is produced by basophils and by mast cells found in nearby connective tissues. Histamine increases the permeability of the capillaries to white blood cells and some proteins, to allow them to engage pathogens in the infected tissues.

Basic Info

Chemical Name	histamine
Synonyms	2-(1H-imidazol-4-yl)ethanamine; Eramine; Histamine; Eramin; Ergamine; 1H-Imidazole-4-ethanamine; HIS ELISA; 2-(4-imidazolyl)-ethyl amine; istamina; Ergotidine; Theramine; 4-(2-aminoethyl)imidazole; HISTAMIN; L-HISTAMINE; 2-(4-imidazolyl)-1-ethylamine; 2-(4-Imidazolyl)ethylamine;
CAS No.	51-45-6
Molecular Formula	C5H9N3
Molecular Weight	111.14500
PSA	54.70000
LogP	0.61120

Properties

Appearance & Physical State	Yellow crystals.
Density	1.14g/cm3
Boiling Point	167ºC (0.8 mmHg)
Melting Point	83-84ºC
Flash Point	180.3ºC
Refractive Index	1.562
Stability	Stable under normal temperatures and pressures.
Storage Condition	-20ºC

Safety Info

RTECS	MS1050000
Hazard Class	6.1(b)
Safety Statements	S22-S26-S36/37
HS Code	2933290090
Packing Group	III
WGK Germany	3
RIDADR	UN 2811
Risk Statements	R22; R36/37/38; R42/43
Hazard Codes	Xn
Symbol	GHS06, GHS08
Caution Statement	P261; P280; P301 + P310; P305 + P351 + P338; P342 + P311
Hazard Declaration	H301; H315; H317; H319; H334; H335
Signal Word	Danger

Synthesis Route

L-histidine→histamine+histidine
L-histidine→histamine
Anguibactin→histamine+2,3-dihydroxybenzoic acid

GC Analysis

Column type	Active phase	Temperature (°C)	Retention Index (I)	Temperature Control Method
Packed	SE-30	-	1500.	temperature ramp
Other	Methyl Silicone	-	1497.	custom temperature program

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Subcutaneous	LDLo - Lowest published lethal dose	Rodent - rat	250 mg/kg	1.Autonomic Nervous System-other (direct) parasympathomimetic 2.Behavioral-convulsions or effect on seizure threshold
Intravenous	LD50 - Lethal dose, 50 percent kill	Rodent - rat	630 mg/kg	1.Lungs, Thorax, or Respiration-dyspnea 2.Lungs, Thorax, or Respiration-other changes
Oral	LD50 - Lethal dose, 50 percent kill	Rodent - mouse	220 mg/kg	1.Details of toxic effects not reported other than lethal dose value

Precursor

L-histidine
2-(1H-imidazol-5-yl)acetonitrile
Anguibactin
monocloridrato di 2-(2-tiono-4-imidazolin-4-il)etilamina

Downstream Product

2-[2-(1H-imidazol-5-yl)ethyl]guanidine
N-[2-(1H-imidazol-5-yl)ethyl]-3-methylbutanamide
4,5,6,7-Tetrahydro-1H-imidazo[4,5-c]pyridine
Carcinine Hydrochloride

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