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hexamethylphosphoric triamide

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Origin: China

Cas No: 680-31-9

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
CAS No.:
680-31-9
Other Names:
HMPA
MF:
C6H18N3OP
EINECS No.:
211-653-8
Place of Origin:
Shandong, China
Type:
Agrochemical Intermediates, Dyestuff Intermediates, Flavor & Fragrance Intermediates, Pharmaceutical Intermediates, Syntheses Material Intermediates
Purity:
99%
Brand Name:
Finerchem
Model Number:
680-31-9
Application:
Organic Intermediate
Appearance:
Colorless liquid
Product name:
Hexamethylphosphoramide
CAS:
680-31-9
Appearence:
Colorless liquid
Molecular formula:
C6H18N3OP
Molecular weight:
179.20
Packaging&Delivery
Packaging Details
Plastic bottle: within10kg
Plastic drum: 10kg and more
Shipping: by sea; by air; by courier (VIP account of TNT, DHL, Fedex and EMS
Port
Qingdao or Shanghai
Lead Time:
Quantity(Kilograms) 1 - 1 >1
Est. Time(days) 2 To be negotiated

Property

CAS No.: 680-31-9 Formula: C6H18N3OP Molecular Weight: 179.20000

Description

Hexamethylphosphoramide, often abbreviated HMPA, is a phosphoramide (i.e. an amide of phosphoric acid) having the formula [(CH3)2N]3PO. This colorless liquid is a useful polar aprotic solvent and additive in organic synthesis.

Basic Info

Chemical Name	hexamethylphosphoric triamide
Synonyms	hexamethyl; HPT; HEXAMETAPOL; tris(dimethylamino)phosphine oxide; hempa; hexamethyl-phosphoric triamide; PO(NMe2)3 (hexamethylphosphorous triamide); HMPTA; hexamethylphosphoric triamide; HMPA; N,N,N',N',N'',N''-hexamethyl-phosphoric triamide; hexamethylphosphoric acid triamide; Phosphoric triamide, hexamethyl-; ENT 50,882; Hexamethylphosphoramide;
CAS No.	680-31-9
Molecular Formula	C6H18N3OP
Molecular Weight	179.20000
PSA	36.60000
LogP	0.77930

Properties

Appearance & Physical State	clear colorless to light amber liquid
Density	1.03
Boiling Point	235ºC
Melting Point	7ºC
Freezing Point	7℃
Flash Point	105ºC
Refractive Index	1.459
Water Solubility	Miscible
Stability	Stable. Incompatible with strong acids, strong oxidizing agents.
Vapor Density	6.18 (vs air)
Vapor Pressure	0.07 mm Hg ( 25 °C)

Safety Info

RTECS	TD0875000
Hazard Class	6.1(b)
Safety Statements	S53-S45
WGK Germany	3
Packing Group	III
RIDADR	2810
Risk Statements	R45; R46
Hazard Codes	T
Symbol	GHS08
Caution Statement	P201; P308 + P313
Hazard Declaration	H340; H350
Signal Word	Danger

Synthesis Route

→hexamethylphosphoric triamide+carbononitridic iodide
→hexamethylphosphoric triamide+3-iodoprop-2-ynenitrile
dimethyl 2-methoxy-3-(tris(dimethylamino)-l<sup>5</sup>-phosphanylidene)succinate→Methanol+hexamethylphosphoric triamide

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Oral	LD50 - Lethal dose, 50 percent kill	Rodent - rat	2650 mg/kg	1.Behavioral-convulsions or effect on seizure threshold 2.Kidney, Ureter, Bladder-hematuria 3.Kidney, Ureter, Bladder-incontinence
Oral	TDLo - Lowest published toxic dose	Rodent - rat	6 gm/kg/60D-C	1.Related to Chronic Data-death
Oral	TDLo - Lowest published toxic dose	Rodent - rat	8640 mg/kg/72D-C	1.Lungs, Thorax, or Respiration-bronchiectasis 2.Lungs, Thorax, or Respiration-fibrosis, focal (pneumoconiosis)

Precursor

4-nitrobenzaldehyde
Hexamethylphosphorous triamide
BIS(DIMETHYLAMINO)PHOSPHORYL CHLORIDE
Triphenylphosphine

Downstream Product

N-[bis(dimethylamino)phosphinimyl]-N-methylmethanamine
N-[chloro(dimethylamino)phosphanyl]-N-methylmethanamine
Methyl pivaloylacetate
2-methylpyridine

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