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herbimycin

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Origin: China

Cas No: 70563-58-5

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 70563-58-5 Formula: C30H42N2O9 Molecular Weight: 574.66200

    Description

    Herbimycin is a benzoquinone ansamycin antibiotic that binds to Hsp90 (Heat Shock Protein 90) and alters its function. HSP90 client proteins play important roles in the regulation of the cell cycle, cell growth, cell survival, apoptosis, angiogenesis and oncogenesis.
    It was originally found by its herbicidal activity, and thus named. The most recent herbimycins to be discovered, herbimycins D-F, were isolated from a Streptomyces isolated from thermal vents associated with the Ruth Mullins coal fire in Appalachian Kentucky.

    Basic Info

    Chemical Name herbimycin
    Synonyms

    Herbimycin A;
    (4E,6Z,8S,9S,10E,12S,13R,14S,16S,17R)-8,13,14,17-tetramethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate;
    (4E,6Z,8S,9S,10E,12S,13R,14S,16S,17R)-9-[(aminocarbonyl)oxy]-8,13,14,17-tetramethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione;
    (15R)-17-demethoxy-15-methoxy-11-O-methylgeldanamycin;

    CAS No. 70563-58-5
    Molecular Formula C30H42N2O9
    Molecular Weight 574.66200
    PSA 152.48000
    LogP 3.74240

    Properties

    Appearance & Physical State yellow powder
    Density 1.19 g/cm3
    Boiling Point 752.4ºC at 760 mmHg
    Flash Point 408.8ºC
    Refractive Index 1.545
    Storage Condition -20ºC

    Safety Info

    Safety Statements S22; S24/25; S36; S26
    HS Code 29419000
    Risk Statements R36/37/38
    Hazard Codes Xi

    Synthesis Route

    →herbimycin
    →herbimycin
    9-(tert-butyl-dimethyl-silanyloxy)-8,13,14,17,20,22-hexamethoxy-4,10,12,16-tetramethyl-2-aza-bicyclo[16.3.1]docosa-1(21),4,6,10,18(22),19-hexaen-3-one→herbimycin

    Precursor




    3-bromo-2,5-dimethoxyaniline

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