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harmine

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Origin: China

Cas No: 442-51-3

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description

  • Quick Details

    CAS No.:
    442-51-3
    Other Names:
    Harmaline
    MF:
    /
    EINECS No.:
    /
    Type:
    Herbal Extract
    Purity:
    98% Pure Extract Powder
    Brand Name:
    Ocean
    Model Number:
    TOP
    Application:
    Food Supplement
    Appearance:
    Brown Yellow Powder
    Sample:
    Avaliable
    Storage:
    Dry place
    Part:
    Seed

    Packaging&Delivery

    Packaging Details
    25kgs packaging Fiber drum outside and plastic bag inside 1-25kgs packaging aluminium bag outside and double plastic bag inside. Harmine
    Lead Time:
    Quantity(Kilograms)1 - 1>1
    Est. Time(days)15To be negotiated

  • Property

    CAS No.: 442-51-3 Formula: C13H12N2O Molecular Weight: 212.24700

    Description

    Harmine, also known as telepathine, is a fluorescent harmala alkaloid belonging to the beta-carboline family of compounds. It occurs in a number of different plants, most notably the Middle Eastern plant harmal or Syrian rue (Peganum harmala) and the South American vine Banisteriopsis caapi (also known as "yage" or "ayahuasca"). Harmine reversibly inhibits monoamine oxidase A (MAO-A), an enzyme which breaks down monoamines, making it a RIMA. Harmine selectively binds to MAO-A but does not inhibit the variant MAO-B.

    Basic Info

    Chemical Name harmine
    Synonyms

    Garmin;
    Telepathien;
    9H-Pyrido[3,4-b]indole, 7-methoxy-1-methyl-;
    Yajeine;
    Yagein;
    Harmine;
    Yageine;
    BANISTERINE MONOHYDRATE;
    Harmin;
    7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole;
    Telepathin;
    Banisterine;

    CAS No. 442-51-3
    Molecular Formula C13H12N2O
    Molecular Weight 212.24700
    PSA 37.91000
    LogP 3.03310

    Properties

    Appearance & Physical State Off-white solid
    Density 1.252g/cm3
    Boiling Point 421.4ºC at 760mmHg
    Melting Point 262-264ºC(lit.)
    Flash Point 139.7ºC
    Refractive Index 1.706
    Storage Condition Refrigerator
    Vapor Pressure 6.42E-07mmHg at 25°C

    Safety Info

    RTECS UV0175000
    Hazard Class 6.1
    Safety Statements S22; S24/25; S36/37; S26; S36
    HS Code 2933990090
    WGK Germany 3
    Packing Group III
    RIDADR UN 1544
    Risk Statements R20/21/22; R36
    Hazard Codes Xn

    Synthesis Route

    Leptaflorine→harmine
    N,N-dimethylacetamide+6-methoxy-1-(phenylsulfonyl)-3-vinyl-1H-indole→harmine
    harmaline→harmine

    Toxicity

    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    Intramuscular TDLo - Lowest published toxic dose Human - man 3 mg/kg 1.Behavioral-sleep
    2.Behavioral-tremor
    3.Gastrointestinal-nausea or vomiting
    Subcutaneous LD50 - Lethal dose, 50 percent kill Rodent - rat 200 mg/kg 1.Details of toxic effects not reported other than lethal dose value
    Subcutaneous LD50 - Lethal dose, 50 percent kill Rodent - mouse 243 mg/kg 1.Behavioral-excitement
    2.Skin and Appendages-hair

    Precursor

    1-(benzenesulfonyl)-6-methoxyindole-3-carbaldehyde
    N,N-dimethylacetamide
    Leptaflorine
    harmaline

    Downstream Product

    HARMOL
    7-hydroxy-1-methyl-9H-β-carboline-6-sulfonic acid
    HARMALOL
    8-methoxycanthin-6-one

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