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GW3965

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Origin: China

Cas No: 405911-09-3

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 405911-09-3 Formula: C33H31ClF3NO3 Molecular Weight: 582.05200

    Description

    GW3965 is a potent, selective liver X receptor (LXR) agonist for hLXRα and hLXR. GW3965 has shown potent anti-inflammatory activity in both irritant and allergic contact models of dermatitis, requiring the participation of both LXRα and LXRβ.

    Basic Info

    Chemical Name GW3965
    Synonyms

    3-(3-(N-(2-Chloro-3-trifluoromethylbenzyl)(2,2-diphenylethyl)amino)propoxy)phenylacetic acid;
    2-(3-(3-((2-chloro-3-(trifluoromethyl)benzyl)(2,2-diphenylethyl)amino)propoxy)phenyl)acetic acid;
    2-[3-[3-[[2-chloro-3-(trifluoromethyl)phenyl]methyl-(2,2-diphenylethyl)amino]propoxy]phenyl]acetic acid;
    3-[3-[N-(2-chloro-3-trifluoromethylbenzyl)-N-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid;
    2-{3-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2,2-diphenylethyl)amino)propoxy]phenyl}acetic acid;
    2-(3-{3-[[2-chloro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino]propoxy}-phenyl)acetic acid;
    (3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-2,2-diphenylethyl-amino]-propoxy}-phenyl)-acetic acid;
    UNII-6JI5YOG7RC;
    (3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenyl)-acetic acid;

    CAS No. 405911-09-3
    Molecular Formula C33H31ClF3NO3
    Molecular Weight 582.05200
    PSA 49.77000
    LogP 8.08910

    Properties

    Density 1.261g/cm3
    Boiling Point 672.4ºC at 760mmHg
    Flash Point 360.5ºC

    Synthesis Route

    (3-{[tert-butyl(dimethyl)silyl]oxy}phenyl)acetic acid+2,2-Diphenylethylamine→GW3965

    Precursor

    (3-{[tert-butyl(dimethyl)silyl]oxy}phenyl)acetic acid
    3-Bromo-1-propanol
    2,2-Diphenylethylamine
    2-CHLORO-3-(TRIFLUOROMETHYL)BENZALDEHYDE

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