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doxylamine

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Origin: China

Cas No: 469-21-6

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Product Description

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CAS No.: 469-21-6 Formula: C17H22N2O Molecular Weight: 270.36900

Description

Doxylamine is a first-generation antihistamine, first reported in 1949. It can be used by itself as a short-term sedative and in combination with other drugs to provide night-time allergy and cold relief. Doxylamine is also used in combination with the analgesics paracetamol (acetaminophen) and codeine as an analgesic/calmative preparation, and is prescribed in combination with vitamin B6 (pyridoxine) to prevent morning sickness in pregnant women. Its fetal safety is “A” in Briggs’ Reference Guide to Foetal and Neonatal Risk.

Basic Info

Chemical Name	doxylamine
Synonyms	Dossilamina; doxilamina; Doxilminio; Doxylamine; Doxylaminum; N,N-dimethyl-2-(1-phenyl-1-pyridin-2-ylethoxy)ethanamine;
CAS No.	469-21-6
Molecular Formula	C17H22N2O
Molecular Weight	270.36900
PSA	25.36000
LogP	2.92330

Properties

Density	1.043 g/cm3
Boiling Point	364.9ºC at 760 mmHg
Flash Point	174.5ºC

Synthesis Route

2-dimethylaminoethyl chloride→doxylamine

GC Analysis

Column type	Active phase	Temperature (°C)	Retention Index (I)	Temperature Control Method
Packed	SE-30	220.	1945.	isothermal
Capillary	SPB-1	250.	1958.	isothermal
Capillary	SPB-1	-	1925.	temperature ramp
Capillary	SE-30	-	1888.	temperature ramp
Capillary	DB-5	-	1890.	temperature ramp