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doxazosin

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Origin: China

Cas No: 74191-85-8

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    CAS No.: 74191-85-8 Formula: C24H29N5O8S Molecular Weight: 547.58100

    Description

    Doxazosin mesylate, a quinazoline compound sold by Pfizer under the brand names Cardura and Carduran, is an α1-selective alpha blocker used to treat high blood pressure and urinary retention associated with benign prostatic hyperplasia (BPH).
    On February 22, 2005, the US FDA approved a sustained release form of doxazosin, to be marketed as Cardura XL.
    It is an alpha-1 adrenergic receptor blocker that inhibits the binding of norepinephrine (released from sympathetic nerve terminals) to the alpha-1 receptors on the membrane of vascular smooth muscle cells. The primary effect of this inhibition is relaxed vascular smooth muscle tone (vasodilation), which decreases peripheral vascular resistance, leading to decreased blood pressure.
    Doxazosin and similar medications like prazosin have been found to help reduce the intensity of and/or stop posttraumatic stress disorder night terrors and nightmares. The full explanation for this effect is not understood.
    In Egypt, tablet formulation sold as Duracin produced by Biopharm group for research and the drug industry, Dosin by Eipico and Doxazocine by Multi-Apex.

    Basic Info

    Chemical Name doxazosin
    Synonyms

    Doxazosine [French];
    1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl]piperazine;
    Doxazosinum;
    Normothen;
    Cardura;
    Doxazosina;
    Doxazosine;
    Cardura-1;
    Cardura-2;
    Cardura-4;
    4-amino-2-[4-(1,4-benzodioxan-2-carbonyl)piperazin-1-yl]-6,7-dimethoxyquinazoline;
    [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(2,3-dihydro-1,4-benzodioxin-3-yl)methanone;

    CAS No. 74191-85-8
    Molecular Formula C24H29N5O8S
    Molecular Weight 547.58100
    PSA 175.02000
    LogP 2.88670

    Properties

    Density 1.371 g/cm3
    Boiling Point 718ºC at 760 mmHg
    Melting Point 289-290ºC
    Flash Point 388ºC

    Safety Info

    RTECS LP8925000
    Safety Statements S36/37; S37/39; S26; S36
    WGK Germany 2
    RIDADR UN 1198 3/PG 3
    Risk Statements R23/24/25; R34; R40; R43; R36/37/38; R38
    Hazard Codes T; Xi

    Synthesis Route

    2-Chloro-4-amino-6,7-dimethoxyquinazoline+2-(1-Piperazinylcarbonyl)-1,4-benzodioxane→doxazosin
    (2,3-dihydrobenzo[b][1,4]dioxin-2-yl)(1H-imidazol-1-yl)methanone+2-Piperazinyl-4-amino-6,7-dimethoxyquinazoline→doxazosin
    Catechol→doxazosin

    Precursor

    2-Chloro-4-amino-6,7-dimethoxyquinazoline
    (2,3-dihydrobenzo[b][1,4]dioxin-2-yl)(1H-imidazol-1-yl)methanone
    2-(1-Piperazinylcarbonyl)-1,4-benzodioxane
    Catechol

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