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donepezil

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Origin: China

Cas No: 120014-06-4

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
CAS No.:
120014-06-4
Other Names:
Donepezil
MF:
C24H29NO3
EINECS No.:
1312995-182-4
Place of Origin:
Shandong, China
Type:
Antibiotic and Antimicrobial Agents
Grade Standard:
Medicine Grade
Usage:
Animal Pharmaceuticals
Brand Name:
QDXIGEMA
Model Number:
TOP
Purity:
99%
Product Name:
Donepezil
MW:
379.49
Melting point:
207°C
Shelf life:
2 Years
Water Solubility:
2.931 mg/L
Color:
white
Form:
powder
Boiling point:
527.9°C at 760mmHg
Density:
1.141g/cm3
Flash point:
273.1°C
Packaging&Delivery
Packaging Details
1.0kgs/Al-foil bag, 5.0 kgs/Al-foil bag, 25.0 kgs/drum or upon customers' request
Port
Qingdao port

Property

CAS No.: 120014-06-4 Formula: C24H29NO3 Molecular Weight: 379.49200

Description

Donepezil, marketed under the trade name Aricept, is a medication used in the palliative treatment of Alzheimer's disease. Donepezil is used to improve cognition and behavior of people with Alzheimer's, but does not slow the progression of or cure the disease.
Common side effects include loss of appetite, gastrointestinal upset, diarrhea, difficulty sleeping, vomiting, or muscle cramping.
It was developed by Eisai and Pfizer and is sold as a generic by multiple suppliers. Donepezil acts as a centrally acting reversible acetylcholinesterase inhibitor.

Basic Info

Chemical Name	donepezil
Synonyms	DONEPEZIL; 2-((1-Benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one; 5,6-Dimethoxy-2,3-dihydro-1H-inden-1-one; n-1-one; Donezepil; 2-[(1-Benzyl-4-piperidyl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one; Donepezil hydrochloride monohydrate; Donepezil Base;
CAS No.	120014-06-4
Molecular Formula	C24H29NO3
Molecular Weight	379.49200
PSA	38.77000
LogP	4.29900

Properties

Appearance & Physical State	white or almost white crystal powder
Density	1.141g/cm3
Boiling Point	527.9ºC at 760mmHg
Melting Point	207ºC
Flash Point	273.1ºC
Refractive Index	1.578
Vapor Pressure	3.11E-11mmHg at 25°C

Safety Info

Safety Statements	S26; S36
RIDADR	UN 2811
Risk Statements	R36/37/38
Hazard Codes	Xi

Synthesis Route

benzyl bromide+5,6-dimethoxy-2-(piperidin-4-ylmethyl)-2,3-dihydroinden-1-one→donepezil
2-((1-Benzylpiperidin-4-yl)methylene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one→donepezil+5,6-dimethoxy-2-(piperidin-4-ylmethyl)-2,3-dihydroinden-1-one
Hydroxy Donepezil→donepezil

Precursor

2-((1-Benzylpiperidin-4-yl)methylene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
5,6-dimethoxy-2-(piperidin-4-ylmethyl)-2,3-dihydroinden-1-one
Hydroxy Donepezil
benzyl chloride

Downstream Product

donepezil hydrochloride monohydrate
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-ol
5,6-dimethoxy-2-(piperidin-4-ylmethyl)-2,3-dihydroinden-1-one
6-O-Desmethyl Donepezil

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