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DMT-2′O-Methyl-rC(ac) Phosphoramidite

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Origin: China

Cas No: 199593-09-4

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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CAS No.: 199593-09-4 Formula: C42H52N5O9P Molecular Weight: 801.86400

Basic Info

Chemical Name	DMT-2′O-Methyl-rC(ac) Phosphoramidite
Synonyms	2'-OMe-Ac-CPhosphoramidite; N-[1-[(2R,3S,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-methoxyoxolan-2-yl]-2-oxopyrimidin-4-yl]acetamide;
CAS No.	199593-09-4
Molecular Formula	C42H52N5O9P
Molecular Weight	801.86400
PSA	169.22000
LogP	6.87418

Synthesis Route

2-cyanoethyl N,N- diisopropylchlorophosphoramidite+N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxy-3-methoxyoxolan-2-yl]-2-oxopyrimidin-4-yl]acetamide→DMT-2′O-Methyl-rC(ac) Phosphoramidite
4,4'-Dimethoxytrityl chloride→DMT-2′O-Methyl-rC(ac) Phosphoramidite
N4-acetyl-1-[3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl]cytosine→DMT-2′O-Methyl-rC(ac) Phosphoramidite

Precursor

N4-acetylcytidine
N4-acetyl-1-[3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl]cytosine
2-cyanoethyl N,N- diisopropylchlorophosphoramidite
N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxy-3-methoxyoxolan-2-yl]-2-oxopyrimidin-4-yl]acetamide

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