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Origin: China
Cas No: 81103-11-9
Specification: 99%min
Min order Quantity: 1 /kg
Supply Ability: 50 mt/month
Lead time: 7 days for OEM, 3 days for ready goods
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Product Name: Clarithromycin
Synonyms: Clarithromycine; Clathromycin, Clarithromycinum
Chemical name: 6-O-Methylerythromycin.
CAS Number: 81103-11-9
Forms: Clarithromycin Granular, Clarithromycin Granule; Clarithromycin Micronized Powder, Clarithromycin Micro Powder
Characteristics: White to off-white crystalline powder.
Assay: 94% Min
Formula: C38H69NO13
Density: 1.18 g/cm3
Melting Range: 217-220ºC
Package information: 25Kgs/Drum; 5KG/Drum, 10KG/Drum
KEY Words: Clarithromycin, Clarithromycine, Clarithromycinum Powder API, Raw Material
Storage: Store only in original container. Keep container tightly closed.
Quality standard: CP/ USP/ IP2014
Description:
Clarithromycin is a semisynthetic macrolide anti-biotic. It derives from erythromycin.
Clarithromycin will inhibit bacteria’s protein synthesis. This inhibits the translocation of aminoacyl transfer-RNA and prevents peptide chain elongation.
Clarithromycin is an antibiotic used to treat various bacterial infections. For example the infections of includes strep throat, pneumonia, skin, H. pylori infection, and Lyme disease. Clarithromycin can be taken orally as a pill or liquid.
Developed in 1980. Clarithromycin is on the WHO's List of Essential Medicines, it is the most important medications needed in a basic health system. Clarithromycin is available as a generic medication. Clarithromycin is made from erythromycin, and it have a chemical name 6-O-methylerythromycin.
Clarithromycin Powder API, Raw Material is a semi-synthetic macrolide antibiotic, which is chemically related to erythromycin and azithromycin. Clarithromycin is effective against a wide variety of bacteria, such as Haemophilus influenzae, mycobacterium avium, Streptococcus pneumoniae, etc. Like all macrolide antibiotics, Clarithromycin Powder API, Raw Material will interfere bacteria’s ability to make proteins, thus the growth will be stopped. Due to the differences in the way proteins are made in bacteria and humans, Clarithromycin will not interfere with production of proteins in humans. Clarithromycin Powder API, Raw Material derived from Streptomyces bacteria. It will inhibit protein synthesis by bacteria at the 50S ribosome. They are characterized by a macrocyclic ring (a large ring molecule with many functional groups bonded to it) and a large lactone ring in the molecular structure. Clarithromycin is usually used to produce medicines which is indicated for tract, skin, and genitourinary infections.
Clarithromycin Inhibits Myometrial Contractions in Isolated Human Myometrium Independent of Stimulus.
Classification:
Clarithromycin Powder API, Raw Material will be classified as Antibacterial, Antibiotic, Anti-infective Agent, Gastrointestinal Agent, Macrolide.
Certificate of Analysis of Clarithromycin
Items |
Specifications |
Results |
|
Appearance Clarithromycin |
White to almost white crystalline powder |
white crystalline powder |
|
Solubility Clarithromycin |
Soluble in acetone;slightly soluble in dehydrated alcohol,in methanol, and in acctonitrile,and in phosphate butter at PH values of 2 to5; practically insoluble in water |
Conforms |
|
Identification Clarithromycin |
IR:conforms to the spectrum of clarithromycin RS |
Conforms |
|
Specific optical rotation |
-94.--102.(anhydrous substance,1 0mg/ml methylene chloride) |
-98. |
|
Sulphated ash |
≤ 0.2% |
<0.01% |
|
Appearance of solution |
Clear or not more opalescent than reference suspension II and not more intensely coloured than reference solutionY7 |
Conforms |
|
Crystallinity |
Meet the requirements |
Conforms |
|
pH |
8.0-10.0 |
8.7 |
|
Water |
≤ 2.0% |
0.35% |
|
Related substances |
(1)any single impurity |
≤ 1.0% |
0.65% |
(2)any impurities greater than 0.4% |
not more than 4 impurities |
1 |
|
(3)total impurities |
≤ 3.5% |
2.0% |
|
Heavy metals |
≤ 0.002% |
2.0% |
|
Residul solvents |
Ethanol ≤ 5000ppm |
Not detected |
|
Pyridine≤220ppm |
Not detected |
||
Assay (on dried basis ) Clarithromycin |
96.0% ~ 102.0%(anhydrous substance) |
97.3% |
|
Conclusion |
It complies with USP38 standard. |
Property
Description
Basic Info
Chemical Name | clarithromycin |
---|---|
Synonyms |
BIAXIN; |
CAS No. | 81103-11-9 |
Molecular Formula | C38H69NO13 |
Molecular Weight | 747.95300 |
PSA | 182.91000 |
LogP | 2.43970 |
Properties
Appearance & Physical State | white to off-white crystalline powder |
---|---|
Density | 1.18 g/cm3 |
Boiling Point | 805.5ºC at 760 mmHg |
Melting Point | 217-220ºC |
Flash Point | 440.9ºC |
Stability | Store in Freezer |
Storage Condition | Store only in original container. Keep container tightly closed. |
Safety Info
RTECS | KF4997000 |
---|---|
Safety Statements | S26; S36 |
HS Code | 29419000 |
Risk Statements | R22 |
Hazard Codes | Xi; Xn |
Synthesis Route
Toxicity
Exposure Route | Type of Test | Species Observed | Dose/Duration | Toxic Effects |
---|---|---|---|---|
Oral | TDLo - Lowest published toxic dose | Human - woman | 30 mg/kg/3D-I | 1.Cardiac-pulse rate increase, without fall in BP 2.Cardiac-change in rate |
Oral | LD50 - Lethal dose, 50 percent kill | Rodent - rat | 1270 mg/kg | 1.Behavioral-changes in motor activity (specific assay) |
Intraperitoneal | LD50 - Lethal dose, 50 percent kill | Rodent - rat | 669 mg/kg | 1.Sense Organs and Special Senses (Eye)-ptosis 2.Behavioral-somnolence (general depressed activity) 3.Lungs, Thorax, or Respiration-respiratory depression |
Precursor
Downstream Product