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17α-Caproyloxyprogesterone

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Origin: China

Cas No: 630-56-8

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

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CAS No.: 630-56-8 Formula: C27H40O4 Molecular Weight: 428.60400

Description

Hydroxyprogesterone caproate (OHPC) (INN, USAN, JAN) (brand names Delalutin, Proluton, Makena, Prodrox, Hylutin, many others), also known as hydroxyprogesterone hexanoate (BANM), is a steroidal progestin and derivative of 17α-hydroxyprogesterone (17α-OHP) that is related to other 17α-OHP derivatives such as chlormadinone acetate, cyproterone acetate, medroxyprogesterone acetate, and megestrol acetate. It is an ester of 17α-OHP formed from caproic acid (hexanoic acid).
OHPC was previously marketed under the trade name Delalutin by Squibb, which was approved by the United States (U.S.) Food and Drug Administration (FDA) in 1956 and withdrawn from marketing in 1999. It is also sold as Proluton throughout Europe. The U.S. FDA approved Makena from KV Pharmaceutical (previously named as Gestiva) on February 4, 2011 for prevention of preterm delivery in women with a history of preterm delivery, sparking a pricing controversy.

Basic Info

Chemical Name	17α-Caproyloxyprogesterone
Synonyms	[(8R,9S,10R,13S,14S,17R)-17-acetyl-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] hexanoate;
CAS No.	630-56-8
Molecular Formula	C27H40O4
Molecular Weight	428.60400
PSA	60.44000
LogP	5.96960

Properties

Appearance & Physical State	White or almost White Crystalline power
Density	1.1 g/cm3
Boiling Point	536.4ºC at 760 mmHg
Melting Point	119ºC
Flash Point	227.6ºC
Refractive Index	1.533

Safety Info

RTECS	TU5085000
Safety Statements	53-22-36/37/39-45
WGK Germany	3
Risk Statements	R61
Hazard Codes	T

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Unreported	TDLo - Lowest published toxic dose	Human - woman	12 mg/kg,female 6-20 week(s) after conception	1.Reproductive-Effects on Newborn-behavioral
Intramuscular	TDLo - Lowest published toxic dose	Rodent - rat	700 mg/kg,female 18-24 day(s) after conception	1.Reproductive-Effects on Embryo or Fetus-fetotoxicity (except death, e.g., stunted fetus) 2.Reproductive-Effects on Embryo or Fetus-fetal death
Implant	TDLo - Lowest published toxic dose	Rodent - rat	30 mg/kg,male 20 day(s) pre-mating	1.Reproductive-Fertility-male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)