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(+)-dexrazoxane

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Origin: China

Cas No: 24584-09-6

Specification: 99%min

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Supply Ability: 100 mt/month

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 24584-09-6 Formula: C11H16N4O4 Molecular Weight: 268.26900

    Description

    Dexrazoxane is a cardioprotective compound against anthracyclines. It is highly protective in reducing anthracycline-induced cardiotoxicity and extravasation injury. It functions by inhibiting topoisomerase II without inducing DNA strand breaks. Dexrazoxane is a + enantiomer of razoxane.

    Basic Info

    Chemical Name (+)-dexrazoxane
    Synonyms

    4-[(2S)-2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione;
    Dexrazoxane;
    (S)-1,2-Bis(3,5-dioxo-1-piperazinyl)propane;

    CAS No. 24584-09-6
    Molecular Formula C11H16N4O4
    Molecular Weight 268.26900
    PSA 98.82000
    LogP -2.17490

    Properties

    Density 1.333 g/cm3
    Boiling Point 531.5ºC at 760 mmHg
    Melting Point 194-196ºC
    Refractive Index 1.539
    Vapor Pressure 2.22E-11mmHg at 25°C

    Safety Info

    HS Code 2933599090
    Signal Word Warning
    Symbol GHS07
    Hazard Declaration H315; H319; H335
    Caution Statement P305 + P351 + P338

    Synthesis Route

    (S)-1,2-diaminopropane-N,N,N',N'-tetraacetic acid methyl ester→(+)-dexrazoxane
    1,2-Diaminopropane-N,N,N',N'-tetraacetic acid→(+)-dexrazoxane

    Precursor

    1,2-Diaminopropane-N,N,N',N'-tetraacetic acid
    (S)-1,2-diaminopropane-N,N,N',N'-tetraacetic acid methyl ester

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